منابع مشابه
Microtubules: Sizing Up the GTP Cap
The 'GTP cap' of the microtubule has long been postulated to exist, but a recent experiment gives us the first quantitative measurements of the cap size in the cell.
متن کاملNanobiomechanical Properties of Microtubules
Microtubules, the active filaments with tubular shapes, play important roles in a wide range of cellular functions, including structural supports, mitosis, cytokinesis, and vesicular transport, which are essential for the growth and division of eukaryotic cells. Finding properties of microtubules is one of the main concerns of scientists. This work helps to obtain mechanical properties of m...
متن کاملEvidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules.
Evidence that 13 or 14 contiguous tubulin-GTP subunits are sufficient to cap and stabilize a microtubule end and that loss of only one of these subunits results in the transition to rapid disassembly(catastrophe) was obtained using the slowly hydrolyzable GTP analogue guanylyl-(a,b)-methylene-diphosphonate (GMPCPP). The minus end of microtubules assembled with GTP was transiently stabilized aga...
متن کاملDetyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap.
Many cell types contain a subset of long-lived, 'stable' microtubules that differ from dynamic microtubules in that they are enriched in post-translationally detyrosinated tubulin (Glu-tubulin). Elevated Glu tubulin does not stabilize the microtubules and the mechanism for the stability of Glu microtubules is not known. We used detergent-extracted cell models to investigate the nature of Glu mi...
متن کاملAttachment of the cap to the central microtubules of Tetrahymena cilia.
The central microtubule cap is bound to the ends of the two central microtubules in Tetrahymena thermophila cilia by plug-shaped structures similar in appearance to the distal filament plugs attached to the ends of the A-microtubules. The caps have been separated from the microtubules and are composed of a bead, two plates, and two peg-like plugs to which the microtubules are attached. The stru...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 1999
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.24.299